So talk to a psychiatrist about this. Not an NP or other, a real psychiatrist.
However, I do know ketamine is useful for TRD, and it’s low dose no need to worry about tripping balls. Electroshock therapy is another useful tool for TRD. Finally Auvelity is a new med that is real good for TRD and depression in general. All are really good, and reported positively by patients.
As for making your anxiety worse? Doubtful. Awakening schizophrenia? Not how it develops so no chance of that.