this post was submitted on 15 Oct 2025
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You know what’s worse for bioprocessing than sticky cells? Bubbles. The article implies this solves everything, when in reality it works on an edge case. Mammalian cells, and most cells lacking a tough outer wall, would never tolerate bubbles.
What happens when they interact with bubbles?
Bubbles act as a water/air interface. The lipid membrane of a cell is a wall that has an internal hydrophobic layer made of phospholipids. Phospholipids when introduced to a water/air interface orient their hydrophobic side into the air, away from water. In other words the bubble rips the cell membrane apart by pulling phospholipids out of the membrane.
Good explanation, thanks!