Cave Johnson.. Love J.K Simmons work overall but Cave was perfect.
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All the Portal characters, really. Cave, GLaDOS, Wheatly, Chell...
Even the turrets!
Are you still there?
My favoriteturret quote:
"Prometheus was punished by the gods for giving the gift of knowledge to man. He was cast into the bowels of the Earth and pecked by birds."
Especially the turrets. I love them so much. The first time I took one down and got hit with the "I don't hate you" 💔 😭
I still tell people I will burn their house down with lemons.

Some of my favorites:
- GLaDOS from Portal 1+2: Ellen McClain did such a fantastic job balancing a monotonous robotic tone with human emotions and adding subtle glitches to show not everything was 100% alright. She defined what a female robot voice should sound like for that decade. I saw that Stephen Merchant was mentioned and while his performance was good and Wheatley's character was hilarious, I think McLain's performance as GLaDOS was more original and memorable.
- Narrator from The Stanley Parable: Kevan Brighting was arguably the protagonist of the game and the player was the annoying mob to him. As the only chacter with dialogue in the entire walking sim game, he had to carry almost the entire game's story, personality, and charm all through his voice. And it's honestly so fun how disappointed, annoyed, and exasperated he gets when the player refuses to listen.
- The Joker from Batman Arkham Asylum: This one is cheating cause Mark Hamill has played The Joker in almost every modern animated medium available. Still, there's a reason his version is so iconic. It's just so bittersweet that he refuses to ever voice The Joker again since Kevin Conroy, the VA for his Batman passed away.
Edit: After reviewing my list, it seems like I like offscreen narrators who insult the player. How funny
The Joker reveal in Arkham City was also some brilliant writing carried through by Hamill's amazing voice acting: https://youtu.be/GvZTjWpuuKw?t=63
I enjoyed having him follow me around throughout Arkham Knight too.
Ellen McClain did such a good, iconic job that she landed herself a role in Pacific Rim as the computer in Gipsy Danger.
Getting the animated series actors to voice the Arkham games was a stroke of genius, though.
How has Baldur's Gate 3 not been mentioned in this thread yet? Huge cast and everyone is going for it. Even the narrator. Especially the narrator.
I agree she is amazing, but Andrew Wincott's Raphael is just so phenomenal, for me it'll only ever be him.
Outside of BG3, I guess I would also say Claudia Black, Jennifer Hale and Lenval Brown (the narrator of Disco Elysium, he is so good!).
Check out the BG3 narrator outtakes on YouTube.
It makes me wish for a version of the game where she is actively snarking the party. Like every good DM should.
The narrator in The Stanley Parable made me lose it so many times.
The whole cast of Team Fortress 2.
I haven't played that game in over a decade, yet if I read any of the lines from the game, I'll still hear their voices loud as day. Even just seeing the word "medic" and I hear Demoman screaming it.
There's not a week goes by where I don't wish Expiration Date got a sequel.
Arthur Morgan in Red Dead 2
Rockstar games have some pretty spectacular stories and acting and they're just getting better, ever since GTA IV/RDR/LA Noire. RDR2 was one of the most heartbreaking and melancholy stories I've ever been told, game or otherwise. It's a different genre, of course, but I have high hopes for GTA VI.
I quite like the work in Max Payne, whoever did it.
Stephen Merchant and JK Simmons do a great job in Portal 2
Vaas from Far Cry 3.
This scene is always such a treat: https://youtu.be/rKMMCPeiQoc
Also ~~Alan Tudyk~~ Stephen Merchant in Portal 2.
Edit: Was just recently watching something with Alan in it and got them mixed up 😅
One of the best villains I can remember from a game, Handsome Jack in Borderlands 2. Maybe he was just written so well, but he was amazing.
Dionysus in hades. Dude amps me up so well I pick him over boons I like better.
Nearly everyone in Hades and Hades 2 have awesome voice actors. I'm particularly fond of Zagreus & Skelly from 1 and Melinoë, Hephaestus & Odysseus from 2. Great game and the VAs kick ass.
I gotta say David Hayter was the first video game voice actor I ever heard of and that’s because of a metal gear solid. I still think solid snake is my favourite game voice acting. Especially if you look at the subtle difference in Snake’s voice depending on the game. It was a complete travesty to have snake voiced by anyone else in 5, but in canon it makes sense i guess
The special zombies in left 4 dead 1 & 2
I know it's super obscure, but there are some YouTube videos compiling each special zombie and it's like god tier sound. I bet they had fun doing it, too.
To this day, I still hype myself up to do weird sounds by listening to those because they're so good.
The voice acting in Hellblade always gives me chills.
Every single line in the Soul Reaver trilogy is a masterpiece.
Here, see for yourself. The intro alone will pull you in and never let go.
I think Hades is the best overall, which has been mentioned here. Everything from Supergiant Games is great. I've seen Disco Elysium mentioned too, which is also great.
But I think one game that is underappreciated and not mentioned here is Horizon: Zero Dawn. Ashley Burch won several awards for her performance as Aloy. I think part of the reason it gets forgotten is that the facial animations in cutscenes are bad, at least in the main game, which led to people just not liking the cutscenes very much. The DLC's animations are pretty good though.
Troy Baker & Ashley Johnson in Last of Us will stay with me for life.
Final Fantasy 3/6. Kefka's laugh will forever be the best evil laugh.
CURSE YOU BAYLE! I HEREBY VOW YOU WILL RUE THIS DAY! BEHOLD, A TRUE DRAKE WARRIOR, AND I, IGON! YOUR FEARS MADE FLESH! SOLID OF SCALE YOU MIGHT BE, FOUL DRAGON, BUT I WILL RIDDLE WITH HOLES YOUR ROTTEN HIDE! WITH A HAIL OF HARPOONS, WITH EVERY LAST DROP OF MY BEING!
There is so much testosterone in that moment that just reading this comment put an extra hair on my chest.
You and me as well.
The first new Wolfenstein was amazing. They got actual German actors to play the nazis and it made a huge difference.
Recency bias because I'm currently playing it, but Cherami Leigh, Keanu Reeves, and Idris Elba — and a ton of others — in Cyberpunk 2077. If you like sci-fi and fantasy, you're covered. Asuna from Sword Art Online. Neo from The Matrix. And Roland from The Dark Tower. The fact that the latter two actors have their characters modeled after them make it more than just voice acting, though. Johnny Silverhand moves like Keanu Reeves in addition to looking like him. And Solomon Reed moves like Idris Elba. That hulking walk he did in Luther? It's all over the Reed character. As for Cherami Leigh, well, you can make V look like whatever you want. You can even make her male, in whole or in part (trans/non-binary characters are possible, they even have a male voice actor).
I'm seeing a ton of great answers in the comments though. Shout-out to the person who said Portal. Ellen McLain has a role in Cyberpunk as well. Early on, in your garage, your car is struck by a robotaxi. The robotaxi's AI owner invites you to come to their facility for a tour as well as repayment as a way of apology, and he also has a mission for you. This AI has "children" that have been acting crazy (and, one of them hit your car) and he wants you to bring them back in. One of them is voiced by Ellen McLain. In her GLaDOS voice and with lines from Portal. It's amazing. They had to have gotten permission from Valve for that little stunt. If you like Portal, it's probably gonna be one of your favorite parts of Cyberpunk.
Cpt. Janeway as Flemeth in the Dragon Age series (especially Origins).
Legacy of Kain: Soul Reaver, for the original PlayStation. All these years later it’s still an amazing standout.
The only two I can think of that haven't been mentioned yet, but I feel must:
Disco Elysium
Skywind
The latter is unreleased, but pretty much all the voice acting is done and the work I've heard is impeccable.
Whoever did the scientist's "ACK!" sound from Half Life 1.
I was very impressed by Cherami Leigh in Cyberpunk 2077. She sent shivers down my spine.
Of course there is Roger Craig Smith from AC II, but I also enjoyed Noah Watts (III) and Steven Piovesan (Rogue).
Dominic Armato (Guybrush Threepwood) is an all time favourite of mine.
Halo master fucking chief! Hell yeah brother